By Andrew Franklin
During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a method referred to as affinity maturation. a number produces antibodies with successively better affinities with repeated publicity to an identical antigen, that's the main through which so much vaccines work.
Affinity maturation will depend on hypermutation, an iterative strategy of mutation at antibody-encoding genes, via optimistic choice of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation can result in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant step forward got here in 2000 with the invention that activation-induced deaminase (AID) is basically required for hypermutation. This used to be in 2002 by way of facts that relief without delay edits the DNA that encodes an antibody in an activated B cellphone. a lot has seeing that been learnt concerning the biochemistry and legislation of reduction, however the mechanism through which it's recruited in particular to antibody-encoding genes continues to be enigmatic. knowing this recruitment is clinically major simply because off-target reduction task at oncogenes may end up in chromosomal translocations and tumorigenesis.
This e-book summarizes the study on reduction within the context of its significant position within the affinity maturation of B cells.
Read or Download Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci PDF
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Extra info for Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci
Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin